Highlights The reported LC-MS/MS method resolved 82 erectile dysfunction (ED) drugs in 10 min. ED drug extraction from different matrices gave recoveries from 92 to111%. The screening method was successfully applied to more than 32 samples. The method is faster and more sensitive than currently used and reported methods. Identification of additional species, in an…

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Highlights Fingerprints might contribute to the health risk evaluation of counterfeit drugs. GC-fingerprints were used to discriminate between genuine and counterfeit medicines. Fingerprints were analyzed using different chemometric techniques. Principal Component Analysis clearly discriminated between genuine and counterfeit. Soft Independent Modelling of Class Analogy generated the best predictive models. Abstract Counterfeit medicines are a global…

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Abstract Pharmaceutical counterfeiting is becoming a serious problem all over the world. This paper presents several of the most important methods used to elucidate this problem including near- and mid-infrared spectroscopy, Raman spectroscopy, isotopic characterization, chromatographic and mass spectrometric approaches. Bunaciu, Andrei A., Şerban Fleschin, and Hassan Y. Aboul-Enein. "Spectroscopic Analytical Methods for Detection of…

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The counterfeiting of pharmaceuticals is a global issue that is expanding each year. The severity of drugs counterfeited has increased from lifestyle drugs to include lifesaving (such as anticancer) types in recent times. The miniaturization of instrumentation has led to out-of-laboratory analysis for product authentication. Raman spectroscopy is ideal for pharmaceutical identifications and has been…

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AbstractSeveral analytical techniques aimed at profiling drugs are deemed costly and time consuming, and may not be promptly available for analysis when required. This paper proposes a method for identifying the analytical techniques providing the most relevant data for classification of drug samples into authentic and unauthentic categories. For that matter, we integrate principal components…

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Highlights We propose a wavenumber selection framework based on a wavenumber importance index. The method increases classification performance using a small wavenumber range. Our propositions are applied to Cialis and Viagra FTIR-ATR data. Abstract Attenuated total reflectance (ATR), a sampling technique by Fourier transform infrared (FTIR) spectroscopy, has been adopted as an analytical tool for…

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Abstract Medicine counterfeiting is a serious worldwide issue, involving networks of manufacture and distribution that are an integral part of industrialized organized crime. Despite the potentially devastating health repercussions involved, legal sanctions are often inappropriate or simply not applied. The difficulty in agreeing on a definition of counterfeiting, the huge profits made by the counterfeiters…

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AbstractThis retrospective study reports data obtained from the National Institute of Criminalistics of the Brazilian Federal Police Department (DPF) on 3676 anabolic products seized between 2006 and 2011. Anabolic androgenic steroids (AAS) were declared on the labels of 96.2% of the products. About one third of the products declared to be from Paraguay, and 14.3%…

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Abstract: The article reports on a 2013 decision which the U.S. Food and Drug Administration and several other international law enforcement and regulatory agencies made to take legal and regulatory action against more than 9,600 web sites from various countries that illegally market unproven prescription drugs to consumers. "Operation Pangea VI: combating sale of unapproved…

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Abstract: Criminal syndicates and terrorist organizations are inherently different, one motivated by profit and the other by political goals. Yet their difference enables them to cooperate for their mutual benefit. Nowhere has this been more evident than in the drug trade; from harvesting and trafficking in illegal substances, it has been an easy transition to counterfeiting…

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